سلسلة الأدوية 12

زائر
amdipine besyate
(am e' di peen)
Nvas

Pegnany ategy

Dg asses
aim hanne-bke
Antiangina dg
Antihypetensive

Theapeti atins
Inhibits the mvement f aim ins ass the membanes f adia and ateia mse es; inhibits tansmembane aim fw, whih ests in the depessin f impse fmatin in speiaized adia paemake es, swing f the veity f ndtin f the adia impse, depessin f myadia ntatiity, and diatin f nay ateies and ateies and peiphea ateies; these effets ead t deeased adia wk, deeased adia xygen nsmptin, and in patients with vasspasti (Pinzmeta's) angina, ineased deivey f xygen t adia es.

Indiatins
· Angina petis de t nay atey spasm (Pinzmeta's vaiant angina)
· hni stabe angina, ane in mbinatin with the agents
· Essentia hypetensin, ane in mbinatin with the antihypetensives

ntaindiatins and atins
· ntaindiated with aegy t amdipine, impaied hepati ena fntin, sik sins syndme, heat bk (send thid degee), atatin.
· se atisy with HF.

Avaiabe fms
Tabets--2.5, 5, 10 mg

Dsages
ADTS
Initiay 5 mg P daiy; dsage may be gaday ineased ve 10–14 days t a maximm dse f 10 mg P daiy.
PEDIATI PATIENTS
Safety and effiay nt estabished.
GEIATI PATIENTS PATIENTS WITH HEPATI IMPAIMENT
Initiay, 2.5 mg P daiy; dsage may be gaday adjsted ve 7–14 days based n inia assessment.

Phamakinetis
te
nset
Peak
a
nknwn
6–12 h


Metabism: Hepati; T12: 30–50 h
Distibtin: sses paenta; may pass int beast mik
Exetin: ine

Advese effets
· NS: Dizziness, ight-headedness, headahe, asthenia, fatige, ethagy
· V: Peiphea edema, ahythmias
· Dematgi: Fshing, ash
· GI: Nasea, abdmina dismft

Inteatins
Dg-dg
· Pssibe ineased sem eves and txiity f yspine if taken nenty

Nsing nsideatins
Assessment
· Histy: Aegy t amdipine, impaied hepati ena fntin, sik sins syndme, heat bk, atatin, HF
· Physia: Skin esins, , edema; P, BP, baseine EG, peiphea pefsin, astatin; , adventitis snds; ive evaatin, GI nma tpt; ive and ena fntin tests, inaysis

Inteventins
· Mnit patient aefy (BP, adia hythm, and tpt) whie adjsting dg t theapeti dse; se speia atin if patient has HF.
· Mnit BP vey aefy if patient is as n nitates.
· Mnit adia hythm egay ding stabiizatin f dsage and peidiay ding ng-tem theapy.
· Administe dg witht egad t meas.

Teahing pints<SPAN>
· Take with meas if pset stmah s.
· These side effets may : nasea, vmiting (sma, feqent meas may hep); headahe (adjst ighting, nise, and tempeate; mediatin may be deed).
· ept iega heatbeat, shtness f beath, sweing f the hands feet, pnned dizziness, nstipatin.

Advese effets in Itai ae mst mmn; thse in Bd ae ife-theatening.