زائر
ampiiin
(am pi si' in)
ampiiin sdim
a:
Ampiin (AN), Ap-Ampi (AN), Maiin, Nv-Ampiiin (AN), N-Ampi (AN), mnipen, Penbitin (AN), Pinipen, Ttaiin
ampiiin sdim
Paentea:
mnipen-N
Pegnany ategy B
Dg asses
Antibiti
Peniiin
Theapeti atins
Bateiida atin against sensitive ganisms; inhibits synthesis f bateia e wa, asing e death.
Indiatins
· Teatment f infetins ased by sseptibe stains f Shigea, Samnea, E. i, H. infenzae, P. miabiis, N. gnheae, entei, gam-psitive ganisms (peniiin G–sensitive staphyi, stepti, pnemi)
· Meningitis ased by Neisseia meningitidis
· nabeed se: pphyaxis in esaean setin in etain high-isk patients
ntaindiatins and atins
· ntaindiated with aegies t peniiins, ephaspins, the aegens.
· se atisy with ena disdes.
Avaiabe fms
apses--250, 500 mg; pwde f a sspensin--125 mg5 m, 250 mg5 m; pwde f injetin--125, 250, 500 mg, 1, 2, 10 g
Dsages
Maximm emmended dsage: 8 mgday; may be given IV, IM, P. se paentea tes f sevee infetins, and swith t a te as sn as pssibe.
· espiaty and sft-tisse infetins:
Patients weighing > 40 kg: 250–500 mg IV IM q 6 h.
Patients weighing < 40 kg: 25–50 mgkgday IM IV in eqay divided dses at 6–8 h intevas.
Patients weighing > 20 kg: 250 mg P q 6 h.
Patients weighing < 20 kg: 50 mgkgday P in eqay divided dses q 6–8 h.
· GI and G infetins, inding wmen with N. gnheae:
Patients weighing > 40 kg: 500 mg IM IV q 6 h.
Patients weighing < 40 kg: 50–100 mgkgday IM IV in eqay divided dses q 6–8 h.
Patients weighing > 20 kg: 500 mg P q 6 h.
Patients weighing < 20 kg: 100 mgkgday P in eqay divided dses q 6–8 h.
· Gna infetins: 500 mg q 6 h f peniiin-sensitive ganism singe dse f 3.5 g P with 1 g pbeneid f patients > 45 kg.
· Bateia meningitis (adt and pediati): 150–200 mgkgday by ntins IV dip and then IM injetins in eqay divided dses q 3–4 h.
· Peventin f bateia endaditis f GI G sgey instmentatin:
Adts: 2 g ampiiin IM IV with gentamiin 1.5 mgkg IM IV within 30 mintes f stating pede. Six hs ate give 1 g ampiiin IM IV 1 g amxiiin P.
Pediati patients: 50 mgkg ampiiin IM IV with 1.5 mgkg gentamiin IM IV within 30 mintes f pede. Six hs ate give 25 mgkg ampiiin IM IV 25 mgkg amxiiin P.
· Peventin f bateia endaditis f denta, a, ppe espiaty pedes:
Adts: 2 g ampiiin IM IV within 30 mintes f pede.
Pediati patients: 50 mgkg ampiiin IM IV within 30 mintes f pede.
· Septiemia (adt and pediati): 150–200 mgkgday IV f at east 3 days, then IM q 3–4 h.
· Sexay tansmitted diseases (adt):
ape vitims: Pphyaxis against infetin. Pegnant wmen and patients aegi t tetayine: 3.5 g ampiiin P with 1 g pbeneid.
Pphyaxis in esaean setin: Singe IV IM dse f 25–100 mgkg immediatey afte d is amped.
Phamakinetis
te
nset
Peak
Datin
a
30 min
2 h
6–8 h
IM
15 min
1 h
6–8 h
IV
Immediate
5 min
6–8 h
Metabism: T12: 1–2 h
Distibtin: sses paenta; passes int beast mik
Exetin: nhanged in the ine
IV fats
Pepaatin: enstitte with steie bateistati wate f injetin; piggybak vias may be enstitted with sdim hide injetin; se enstitted stin within 1 h. D nt mix in the same IV stin as the antibitis. se within 1 h afte pepaatin bease pteny may deease signifianty afte that.
Infsin: Diet IV administatin; give swy ve 3–5 min. apid administatin an ead t nvsins.
IV dip: dite as abve befe fthe ditin.
IV piggybak: administe ane fthe dite with mpatibe stin.
mpatibiity: Ampiiin is mpatibe with 0.9% sdim hide, 5% dextse in wate, 0.45% sdim hide stin, 10% invet sga wate, M6 sdim atate stin, atated inge's stin, steie wate f injetin. Dited stins ae stabe f 2–8 h; hek manfate's insets f speifis. Disad stin afte atted time peid.
Inmpatibiity: D nt mix with idaine, veapami, the antibitis, dextse stins.
Y-site inmpatibiity: D nt give with epinephine, hydaazine, ndansetn.
Advese effets
· NS: ethagy, hainatins, seizes
· V: HF
· GI: Gssitis, stmatitis, gastitis, se mth, fy tnge, bak “haiy” tnge, nasea, vmiting, diahea, abdmina pain, bdy diahea, enteitis, psedmembans itis, nnspeifi hepatitis
· G: Nephitis
· Hematgi: Anemia, thmbytpenia, ekpenia, netpenia, pnged beeding time
· Hypesensitivity: ash, feve, wheezing, anaphyaxis
· a: Pain, phebitis, thmbsis at injetin site (paentea)
· the: Speinfetins--a and eta mniiasis, vaginitis
Inteatins
Dg-dg
· Ineased ampiiin effet with pbeneid
· Ineased isk f ash with apin
· Ineased beeding effet with hepain, a antiagants
· Deeased effetiveness with tetayines, hampheni
· Deeased effiay f a ntaeptives, aten with ampiiin
Dg-fd
· a ampiiin may be ess effetive with fd; take n an empty stmah
Dg-ab test
· Fase-psitive mbs' test if given IV
· Deease in pasma estgen nentatins in pegnant wmen
· Fase-psitive ine gse tests if initest, Benedit's stin, Fehing's stin is sed; enzymati gse xidase methds (inistix, Tes-Tape) shd be sed t hek ine gse
Nsing nsideatins
Assessment
· Histy: Aegies t peniiins, ephaspins, the aegens; ena disdes; atatin
· Physia: te infeted aea; skin , esin; , adventitis snds; bwe snds; B, ive and ena fntin tests, sem eetytes, hematit, inaysis
Inteventins
· te infeted aea befe teatment; ete aea if espnse is nt as expeted.
· hek IV site aefy f signs f thmbsis dg eatin.
· D nt give IM injetins in the same site; atphy an . Mnit injetin sites.
· Administe a dg n an empty stmah, 1 h befe 2 h afte meas with a f gass f wate--n fit jie sft dinks.
Teahing pints
· Take this dg and the k.
· Take the f se f theapy; d nt stp taking the dg if y fee bette.
· Take the a dg n an empty stmah, 1 h befe 2 h afte meas; the a stin is stabe f 7 days at m tempeate.
· This antibiti is speifi t y pbem and shd nt be sed t sef-teat the infetins.
· These side effets may : nasea, vmiting, GI pset (sma feqent meas may hep), diahea.
· ept pain dismft at sites, nsa beeding bising, mth ses, ash, hives, feve, ithing, sevee diahea, diffity beathing.
Advese effets in Itai ae mst mmn; thse in Bd ae ife-theatening.
(am pi si' in)
ampiiin sdim
a:
Ampiin (AN), Ap-Ampi (AN), Maiin, Nv-Ampiiin (AN), N-Ampi (AN), mnipen, Penbitin (AN), Pinipen, Ttaiin
ampiiin sdim
Paentea:
mnipen-N
Pegnany ategy B
Dg asses
Antibiti
Peniiin
Theapeti atins
Bateiida atin against sensitive ganisms; inhibits synthesis f bateia e wa, asing e death.
Indiatins
· Teatment f infetins ased by sseptibe stains f Shigea, Samnea, E. i, H. infenzae, P. miabiis, N. gnheae, entei, gam-psitive ganisms (peniiin G–sensitive staphyi, stepti, pnemi)
· Meningitis ased by Neisseia meningitidis
· nabeed se: pphyaxis in esaean setin in etain high-isk patients
ntaindiatins and atins
· ntaindiated with aegies t peniiins, ephaspins, the aegens.
· se atisy with ena disdes.
Avaiabe fms
apses--250, 500 mg; pwde f a sspensin--125 mg5 m, 250 mg5 m; pwde f injetin--125, 250, 500 mg, 1, 2, 10 g
Dsages
Maximm emmended dsage: 8 mgday; may be given IV, IM, P. se paentea tes f sevee infetins, and swith t a te as sn as pssibe.
· espiaty and sft-tisse infetins:
Patients weighing > 40 kg: 250–500 mg IV IM q 6 h.
Patients weighing < 40 kg: 25–50 mgkgday IM IV in eqay divided dses at 6–8 h intevas.
Patients weighing > 20 kg: 250 mg P q 6 h.
Patients weighing < 20 kg: 50 mgkgday P in eqay divided dses q 6–8 h.
· GI and G infetins, inding wmen with N. gnheae:
Patients weighing > 40 kg: 500 mg IM IV q 6 h.
Patients weighing < 40 kg: 50–100 mgkgday IM IV in eqay divided dses q 6–8 h.
Patients weighing > 20 kg: 500 mg P q 6 h.
Patients weighing < 20 kg: 100 mgkgday P in eqay divided dses q 6–8 h.
· Gna infetins: 500 mg q 6 h f peniiin-sensitive ganism singe dse f 3.5 g P with 1 g pbeneid f patients > 45 kg.
· Bateia meningitis (adt and pediati): 150–200 mgkgday by ntins IV dip and then IM injetins in eqay divided dses q 3–4 h.
· Peventin f bateia endaditis f GI G sgey instmentatin:
Adts: 2 g ampiiin IM IV with gentamiin 1.5 mgkg IM IV within 30 mintes f stating pede. Six hs ate give 1 g ampiiin IM IV 1 g amxiiin P.
Pediati patients: 50 mgkg ampiiin IM IV with 1.5 mgkg gentamiin IM IV within 30 mintes f pede. Six hs ate give 25 mgkg ampiiin IM IV 25 mgkg amxiiin P.
· Peventin f bateia endaditis f denta, a, ppe espiaty pedes:
Adts: 2 g ampiiin IM IV within 30 mintes f pede.
Pediati patients: 50 mgkg ampiiin IM IV within 30 mintes f pede.
· Septiemia (adt and pediati): 150–200 mgkgday IV f at east 3 days, then IM q 3–4 h.
· Sexay tansmitted diseases (adt):
ape vitims: Pphyaxis against infetin. Pegnant wmen and patients aegi t tetayine: 3.5 g ampiiin P with 1 g pbeneid.
Pphyaxis in esaean setin: Singe IV IM dse f 25–100 mgkg immediatey afte d is amped.
Phamakinetis
te
nset
Peak
Datin
a
30 min
2 h
6–8 h
IM
15 min
1 h
6–8 h
IV
Immediate
5 min
6–8 h
Metabism: T12: 1–2 h
Distibtin: sses paenta; passes int beast mik
Exetin: nhanged in the ine
IV fats
Pepaatin: enstitte with steie bateistati wate f injetin; piggybak vias may be enstitted with sdim hide injetin; se enstitted stin within 1 h. D nt mix in the same IV stin as the antibitis. se within 1 h afte pepaatin bease pteny may deease signifianty afte that.
Infsin: Diet IV administatin; give swy ve 3–5 min. apid administatin an ead t nvsins.
IV dip: dite as abve befe fthe ditin.
IV piggybak: administe ane fthe dite with mpatibe stin.
mpatibiity: Ampiiin is mpatibe with 0.9% sdim hide, 5% dextse in wate, 0.45% sdim hide stin, 10% invet sga wate, M6 sdim atate stin, atated inge's stin, steie wate f injetin. Dited stins ae stabe f 2–8 h; hek manfate's insets f speifis. Disad stin afte atted time peid.
Inmpatibiity: D nt mix with idaine, veapami, the antibitis, dextse stins.
Y-site inmpatibiity: D nt give with epinephine, hydaazine, ndansetn.
Advese effets
· NS: ethagy, hainatins, seizes
· V: HF
· GI: Gssitis, stmatitis, gastitis, se mth, fy tnge, bak “haiy” tnge, nasea, vmiting, diahea, abdmina pain, bdy diahea, enteitis, psedmembans itis, nnspeifi hepatitis
· G: Nephitis
· Hematgi: Anemia, thmbytpenia, ekpenia, netpenia, pnged beeding time
· Hypesensitivity: ash, feve, wheezing, anaphyaxis
· a: Pain, phebitis, thmbsis at injetin site (paentea)
· the: Speinfetins--a and eta mniiasis, vaginitis
Inteatins
Dg-dg
· Ineased ampiiin effet with pbeneid
· Ineased isk f ash with apin
· Ineased beeding effet with hepain, a antiagants
· Deeased effetiveness with tetayines, hampheni
· Deeased effiay f a ntaeptives, aten with ampiiin
Dg-fd
· a ampiiin may be ess effetive with fd; take n an empty stmah
Dg-ab test
· Fase-psitive mbs' test if given IV
· Deease in pasma estgen nentatins in pegnant wmen
· Fase-psitive ine gse tests if initest, Benedit's stin, Fehing's stin is sed; enzymati gse xidase methds (inistix, Tes-Tape) shd be sed t hek ine gse
Nsing nsideatins
Assessment
· Histy: Aegies t peniiins, ephaspins, the aegens; ena disdes; atatin
· Physia: te infeted aea; skin , esin; , adventitis snds; bwe snds; B, ive and ena fntin tests, sem eetytes, hematit, inaysis
Inteventins
· te infeted aea befe teatment; ete aea if espnse is nt as expeted.
· hek IV site aefy f signs f thmbsis dg eatin.
· D nt give IM injetins in the same site; atphy an . Mnit injetin sites.
· Administe a dg n an empty stmah, 1 h befe 2 h afte meas with a f gass f wate--n fit jie sft dinks.
Teahing pints
· Take this dg and the k.
· Take the f se f theapy; d nt stp taking the dg if y fee bette.
· Take the a dg n an empty stmah, 1 h befe 2 h afte meas; the a stin is stabe f 7 days at m tempeate.
· This antibiti is speifi t y pbem and shd nt be sed t sef-teat the infetins.
· These side effets may : nasea, vmiting, GI pset (sma feqent meas may hep), diahea.
· ept pain dismft at sites, nsa beeding bising, mth ses, ash, hives, feve, ithing, sevee diahea, diffity beathing.
Advese effets in Itai ae mst mmn; thse in Bd ae ife-theatening.