زائر
The 2nd :
ayvi (aygansine)
(ay sye' ke ve)
Ati-Ayvi (AN), Aviax (AN), Zviax
Pegnany ategy B
Dg ass
Antivia
Theapeti atins
Antivia ativity; inhibits via DNA epiatin
Indiatins
· Initia and eent msa and tanes hepes simpex vis (HSV) 1 and 2 and vaiea zste infetins in immnmpmised patients
· Sevee initia and eent genita hepes infetins in seeted patients
· Hepes simpex enephaitis in patients > 6 m
· Ate teatment f hepes zste (shinges) and hikenpx
· intment: initia HSV genita infetins; imited mtanes HSV infetins in immnmpmised patients
· nabeed ses: ytmegavis and HSV infetin fwing tanspant, hepes simpex infetins, vaiea pnemnia, disseminated pimay ezema hepetim
ntaindiatins and atins
· ntaindiated with aegy t ayvi, seizes, HF, ena disease, atatin; se atin with pegnany.
Avaiabe fms
Tabets--400, 800 mg; apses--200 mg; sspensin--200 mg5 m; pwde f injetin--500 mgvia, 1,000 mgvia; injetin--50 mgm; intment--50 mgg
Dsages
ADTS
Paentea
5–10 mgkg infsed IV ve 1 h, q 8 h (15 mgkgday) f 7 days.
a
· Initia genita hepes: 200 mg q 4 h whie awake (1,000 mgday) f 10 days.
· ng-tem sppessive theapy: 400 mg bid f p t 12 m.
· Ate hepes zste: 800 mg q 4 h f 7–10 days.
· hikenpx: 800 mg qid f 5 days.
PEDIATI PATIENTS
Paentea
· < 12 y: 250–500 mgm2 infsed IV ve 1 h, q 8 h (750 mgm2day) f 7 days.
· > 12 y: adt dsage.
a
Safety nt estabished in hiden < 2 y. > 2 y: 20 mgkg pe dse qid (80 mgkgday) f 5 days. hiden > 40 kg shd eeive adt dse.
GEIATI PATIENTS PATIENTS WITH ENA IMPAIMENT
a
eatinine eaane < 10 mmin: 200 mg q 12 h.
IV
eatinine eaane (mmin)
Dsage (IV)
> 50
5 mgkg q 8 h
25–50
5 mgkg q 12 h
10–25
5 mgkg daiy
0–10
2.5 mgkg daiy
Tpia
intment (a ages): Appy sffiient qantity t ve a esins 6 timesday (q 3 h) f 7 days; 1.25-m (0.5-in) ibbn f intment ves 2.5 m2 (4 in2) sfae aea.
Phamakinetis
te
nset
Peak
Datin
a
Vaies
1.5–2 h
IV
Immediate
1 h
8 h
Metabism: T12: 2.5–5 h
Distibtin: sses paenta; entes beast mik
Exetin: nhanged in ine
IV fats
Pepaatin: enstitte 500 mg via in 10 m steie wate f injetin bateistati wate f injetin ntaining benzy ah, 1,000 mg via in 20 m; nentatin wi be 50 mgm. D nt dite dg with bateistati wate ntaining paabens. se enstitted stin within 12 h; dite IV stin t nentatin f 7 mgm ess. D nt se bigi ida fids sh as bd pdts ptein stins. Wam dg t m tempeate t dissve peipitates fmed ding efigeatin.
Infsin: Administe by sw IV infsin f paentea stins; avid bs apid injetin. Infse ve at east 1 h t avid ena damage.
Inmpatibiities: D nt mix with ditiazem, dbtamine, dpamine, fdaabine, fsanet, idabiin, mepeidine, mphine, ndansetn, pipeaiin, sagamstim, vinebine.
Advese effets
Systemi administatin
· NS: Headahe, vetig, depessin, tems, enephapathi hanges
· Dematgi: Infammatin phebitis at injetin sites, ash, hai ss
· GI: Nasea, vmiting, diahea, anexia
· G: ystaia with apid IV administatin, hematia
Tpia administatin
· Dematgi: Tansient bning at site f appiatin
Inteatins
Systemi administatin
Dg-dg
· Ineased effets with pbeneid
· Ineased nephtxiity with the nephtxi dgs
· Exteme dwsiness with zidvdine
Nsing nsideatins
Assessment
· Histy: Aegy t ayvi, seizes, HF, ena disease, atatin, pegnany
· Physia: Skin , esins; ientatin; BP, P, astatin, pefsin, edema; , adventitis snds; inay tpt; BN, eatinine eaane
Inteventins
Systemi administatin
· Ense that the patient is we hydated.
Tpia administatin
· Stat teatment as sn as pssibe afte nset f signs and symptms.
· Wea a bbe gve finge t when appying dg.
Teahing pints
Systemi administatin
· mpete the f se f a theapy, and d nt exeed the pesibed dse.
· a ayvi is nt a e f y disease bt shd make y fee bette.
· These side effets may : nasea, vmiting, ss f appetite, diahea; headahe, dizziness.
· Avid sexa intese whie visibe esins ae pesent.
· ept diffity inating, ash, ineased seveity feqeny f eenes.
Tpia administatin
· Wea bbe gves finge ts when appying the dg t pevent atinatin f the sites and tansmissin t thes.
· This dg des nt e the disease; appiatin ding symptm-fee peids wi nt pevent eenes.
· Avid sexa intese whie visibe esins ae pesent.
· This dg may ase bning, stinging, ithing, ash; ntify y physiian if these ae pnned.
Advese effets in Itai ae mst mmn; thse in Bd ae ife-theatening.
ayvi (aygansine)
(ay sye' ke ve)
Ati-Ayvi (AN), Aviax (AN), Zviax
Pegnany ategy B
Dg ass
Antivia
Theapeti atins
Antivia ativity; inhibits via DNA epiatin
Indiatins
· Initia and eent msa and tanes hepes simpex vis (HSV) 1 and 2 and vaiea zste infetins in immnmpmised patients
· Sevee initia and eent genita hepes infetins in seeted patients
· Hepes simpex enephaitis in patients > 6 m
· Ate teatment f hepes zste (shinges) and hikenpx
· intment: initia HSV genita infetins; imited mtanes HSV infetins in immnmpmised patients
· nabeed ses: ytmegavis and HSV infetin fwing tanspant, hepes simpex infetins, vaiea pnemnia, disseminated pimay ezema hepetim
ntaindiatins and atins
· ntaindiated with aegy t ayvi, seizes, HF, ena disease, atatin; se atin with pegnany.
Avaiabe fms
Tabets--400, 800 mg; apses--200 mg; sspensin--200 mg5 m; pwde f injetin--500 mgvia, 1,000 mgvia; injetin--50 mgm; intment--50 mgg
Dsages
ADTS
Paentea
5–10 mgkg infsed IV ve 1 h, q 8 h (15 mgkgday) f 7 days.
a
· Initia genita hepes: 200 mg q 4 h whie awake (1,000 mgday) f 10 days.
· ng-tem sppessive theapy: 400 mg bid f p t 12 m.
· Ate hepes zste: 800 mg q 4 h f 7–10 days.
· hikenpx: 800 mg qid f 5 days.
PEDIATI PATIENTS
Paentea
· < 12 y: 250–500 mgm2 infsed IV ve 1 h, q 8 h (750 mgm2day) f 7 days.
· > 12 y: adt dsage.
a
Safety nt estabished in hiden < 2 y. > 2 y: 20 mgkg pe dse qid (80 mgkgday) f 5 days. hiden > 40 kg shd eeive adt dse.
GEIATI PATIENTS PATIENTS WITH ENA IMPAIMENT
a
eatinine eaane < 10 mmin: 200 mg q 12 h.
IV
eatinine eaane (mmin)
Dsage (IV)
> 50
5 mgkg q 8 h
25–50
5 mgkg q 12 h
10–25
5 mgkg daiy
0–10
2.5 mgkg daiy
Tpia
intment (a ages): Appy sffiient qantity t ve a esins 6 timesday (q 3 h) f 7 days; 1.25-m (0.5-in) ibbn f intment ves 2.5 m2 (4 in2) sfae aea.
Phamakinetis
te
nset
Peak
Datin
a
Vaies
1.5–2 h
IV
Immediate
1 h
8 h
Metabism: T12: 2.5–5 h
Distibtin: sses paenta; entes beast mik
Exetin: nhanged in ine
IV fats
Pepaatin: enstitte 500 mg via in 10 m steie wate f injetin bateistati wate f injetin ntaining benzy ah, 1,000 mg via in 20 m; nentatin wi be 50 mgm. D nt dite dg with bateistati wate ntaining paabens. se enstitted stin within 12 h; dite IV stin t nentatin f 7 mgm ess. D nt se bigi ida fids sh as bd pdts ptein stins. Wam dg t m tempeate t dissve peipitates fmed ding efigeatin.
Infsin: Administe by sw IV infsin f paentea stins; avid bs apid injetin. Infse ve at east 1 h t avid ena damage.
Inmpatibiities: D nt mix with ditiazem, dbtamine, dpamine, fdaabine, fsanet, idabiin, mepeidine, mphine, ndansetn, pipeaiin, sagamstim, vinebine.
Advese effets
Systemi administatin
· NS: Headahe, vetig, depessin, tems, enephapathi hanges
· Dematgi: Infammatin phebitis at injetin sites, ash, hai ss
· GI: Nasea, vmiting, diahea, anexia
· G: ystaia with apid IV administatin, hematia
Tpia administatin
· Dematgi: Tansient bning at site f appiatin
Inteatins
Systemi administatin
Dg-dg
· Ineased effets with pbeneid
· Ineased nephtxiity with the nephtxi dgs
· Exteme dwsiness with zidvdine
Nsing nsideatins
Assessment
· Histy: Aegy t ayvi, seizes, HF, ena disease, atatin, pegnany
· Physia: Skin , esins; ientatin; BP, P, astatin, pefsin, edema; , adventitis snds; inay tpt; BN, eatinine eaane
Inteventins
Systemi administatin
· Ense that the patient is we hydated.
Tpia administatin
· Stat teatment as sn as pssibe afte nset f signs and symptms.
· Wea a bbe gve finge t when appying dg.
Teahing pints
Systemi administatin
· mpete the f se f a theapy, and d nt exeed the pesibed dse.
· a ayvi is nt a e f y disease bt shd make y fee bette.
· These side effets may : nasea, vmiting, ss f appetite, diahea; headahe, dizziness.
· Avid sexa intese whie visibe esins ae pesent.
· ept diffity inating, ash, ineased seveity feqeny f eenes.
Tpia administatin
· Wea bbe gves finge ts when appying the dg t pevent atinatin f the sites and tansmissin t thes.
· This dg des nt e the disease; appiatin ding symptm-fee peids wi nt pevent eenes.
· Avid sexa intese whie visibe esins ae pesent.
· This dg may ase bning, stinging, ithing, ash; ntify y physiian if these ae pnned.
Advese effets in Itai ae mst mmn; thse in Bd ae ife-theatening.