زائر
aendnate sdim
(ah en' d nate)
Fsamax
Pegnany ategy
Dg asses
Bisphsphnate
aim egat
Theapeti atins
Sws nma and abnma bne esptin witht inhibiting bne fmatin and mineaizatin.
Indiatins
· Teatment and peventin f stepsis in pstmenpasa wmen
· Teatment f men with stepsis
· Teatment f gtiid-inded stepsis
· Teatment f Paget's disease f bne in patients with akaine phsphatase at east tw times ppe imit f nma, thse wh ae symptmati, thse at isk f fte mpiatins
ntaindiatins and atins
· ntaindiated withaegy t biphsphnates; hypaemia, pegnany, atatin.
· se atisy with ena dysfntin, ppe GI disease.
Avaiabe fms
Tabets--5, 10, 35, 40, 70 mg
Dsages
ADTS
· Pstmenpasa stepsis: 10 mgday P in AM with f gass f wate, at east 30 min befe the fist beveage, fd, mediatin f the day, 70 mg P ne a week.
· Maes with stepsis: 10 mgday P.
· Peventin f stepsis: 5 mgday P 35 mg P ne a week.
· Paget's disease: 40 mgday P in AM with f gass f wate, at east 30 min befe the fist beveage, fd, mediatin f the day f 6 m; may eteat afte 6-m teatment-fee peid.
· Gtiid-inded stepsis: 5 mgday P with aim and vitamin D.
PEDIATI PATIENTS
Safety and effiay nt estabished.
PATIENTS WITH ENA IMPAIMENT
Dsage adjstment nt neessay f eatinine eaane 35–60 mmin; nt emmended if eatinine eaane < 35 mmin.
Phamakinetis
te
nset
Datin
P
Sw
Days
Metabism: Nt metabized
Distibtin: sses paenta; may ente beast mik
Exetin: ine
Advese effets
· NS: Headahe
· GI: Nasea, diahea
· Skeeta: Ineased eent bne pain, fa stemaaia
Inteatins
Dg-dg
· Ineased isk f GI distess with aspiin
· Deeased absptin if taken with antaids, aim, in, mtivaent atins; sepaate dsing by at east 30 min
Dg-fd
· Signifianty deeased absptin and sem eves if taken with fd; sepaate dsing fm fd and beveage by at east 30 min
Nsing nsideatins
INIA AET!
Name nfsin has ed between Fsamax (aendnate) and Fmax (tamssin); se atin.
Assessment
· Histy: Aegy t bisphsphnates, ena faie, ppe GI disease, atatin, pegnany
· Physia: Mse tne, bne pain; bwe snds; inaysis, sem aim
Inteventins
· Give in AM with f gass f wate at east 30 min befe the fist beveage, fd, mediatin f the day. Patient mst stay pight f 30 min.
· Mnit sem aim eves befe, ding, and afte theapy.
· emmend nmitant hmne epaement theapy in teatment f stepsis.
· Ense 6-m est peid afte teatment f Paget's disease if eteatment is eqied.
· Ense adeqate vitamin D and aim intake.
· Pvide mft meases if bne pain etns.
Teahing pints
· Take dg in mning with a f gass f pain wate (nt minea wate), at east 30 min befe any beveage, fd, mediatin, and stay pight f 30 min.
· These side effets may : nasea, diahea; bne pain, headahe (anagesi may hep).
· ept twithing, mse spasms, dak-ed ine, sevee diahea.
Advese effets in Itai ae mst mmn; thse in Bd ae ife-theatening.
(ah en' d nate)
Fsamax
Pegnany ategy
Dg asses
Bisphsphnate
aim egat
Theapeti atins
Sws nma and abnma bne esptin witht inhibiting bne fmatin and mineaizatin.
Indiatins
· Teatment and peventin f stepsis in pstmenpasa wmen
· Teatment f men with stepsis
· Teatment f gtiid-inded stepsis
· Teatment f Paget's disease f bne in patients with akaine phsphatase at east tw times ppe imit f nma, thse wh ae symptmati, thse at isk f fte mpiatins
ntaindiatins and atins
· ntaindiated withaegy t biphsphnates; hypaemia, pegnany, atatin.
· se atisy with ena dysfntin, ppe GI disease.
Avaiabe fms
Tabets--5, 10, 35, 40, 70 mg
Dsages
ADTS
· Pstmenpasa stepsis: 10 mgday P in AM with f gass f wate, at east 30 min befe the fist beveage, fd, mediatin f the day, 70 mg P ne a week.
· Maes with stepsis: 10 mgday P.
· Peventin f stepsis: 5 mgday P 35 mg P ne a week.
· Paget's disease: 40 mgday P in AM with f gass f wate, at east 30 min befe the fist beveage, fd, mediatin f the day f 6 m; may eteat afte 6-m teatment-fee peid.
· Gtiid-inded stepsis: 5 mgday P with aim and vitamin D.
PEDIATI PATIENTS
Safety and effiay nt estabished.
PATIENTS WITH ENA IMPAIMENT
Dsage adjstment nt neessay f eatinine eaane 35–60 mmin; nt emmended if eatinine eaane < 35 mmin.
Phamakinetis
te
nset
Datin
P
Sw
Days
Metabism: Nt metabized
Distibtin: sses paenta; may ente beast mik
Exetin: ine
Advese effets
· NS: Headahe
· GI: Nasea, diahea
· Skeeta: Ineased eent bne pain, fa stemaaia
Inteatins
Dg-dg
· Ineased isk f GI distess with aspiin
· Deeased absptin if taken with antaids, aim, in, mtivaent atins; sepaate dsing by at east 30 min
Dg-fd
· Signifianty deeased absptin and sem eves if taken with fd; sepaate dsing fm fd and beveage by at east 30 min
Nsing nsideatins
INIA AET!
Name nfsin has ed between Fsamax (aendnate) and Fmax (tamssin); se atin.
Assessment
· Histy: Aegy t bisphsphnates, ena faie, ppe GI disease, atatin, pegnany
· Physia: Mse tne, bne pain; bwe snds; inaysis, sem aim
Inteventins
· Give in AM with f gass f wate at east 30 min befe the fist beveage, fd, mediatin f the day. Patient mst stay pight f 30 min.
· Mnit sem aim eves befe, ding, and afte theapy.
· emmend nmitant hmne epaement theapy in teatment f stepsis.
· Ense 6-m est peid afte teatment f Paget's disease if eteatment is eqied.
· Ense adeqate vitamin D and aim intake.
· Pvide mft meases if bne pain etns.
Teahing pints
· Take dg in mning with a f gass f pain wate (nt minea wate), at east 30 min befe any beveage, fd, mediatin, and stay pight f 30 min.
· These side effets may : nasea, diahea; bne pain, headahe (anagesi may hep).
· ept twithing, mse spasms, dak-ed ine, sevee diahea.
Advese effets in Itai ae mst mmn; thse in Bd ae ife-theatening.