زائر
Theapy tns patients' es int ane smat bmbs
PSTED: 9:52 p.m. EDT, Agst 31, 2006
va ikExpie = "-1";By histy Feig
NN
Adjst fnt size:
BETHESDA, Mayand (NN) -- Instead f sing sgey, hemtheapy, adiatin, eseahes fm the Natina Instittes f Heath ae finding s-fa imited bt inspiing sess in a new appah f fighting ane, sing the immne system t attak the tms the way it wd a d f.
The hman immne system desn't say fight ane n its wn, s D. Steven senbeg and his NIH eages ae tying t genetiay enginee it, sing a vis they eated in the ab that seeks t ane tms and attahes t them.
senbeg's idea: Mix the es that seek t the ane with the immne es that desty things and see whethe it wd eate a st f smat bmb f the ane. (senbeg: 'Jst a stat')
In the stdy, senbeg tested the appah in 17 patients with advaned meanma, a danges fm f skin ane. A the nventina teatments f the disease aeady had faied in a f the patients.
In 15 f the patients senbeg's engineeed immne-e teatment didn't wk, bt in tw f the patients the ane seems t have mpetey disappeaed. The findings ae pbished in this week's isse f the jna Siene. (Wath hw teatment tk dad dwn the aise -- 3:06)
The finding has eated exitement and hpe amng ane expets. D. Phiip Geenbeg f the nivesity f Washingtn Sh f Mediine aed it "the beginning f a new hapte in teating ane patients."
ne f the patients in whm the teatment seeded is Mak ige fm Watetwn, Wisnsin.
He was fist fnd t have meanma in 1999 in a me n his bak. Afte sgey, it went away. Bt thee yeas ate the ane ame bak. He tied many teatments bt by 2004 nthing was wking, and the ane had spead t his ive.
"I was jst petty mh devastated when I fnd t I did nt espnd," he says. "ight abt that time my daghte gt engaged and I knew thee was ging t be a wedding ming p, s thee was nen. I wanted t be thee."
Thgh nine eseah, his wife fnd senbeg's inia tia at the Natina Instittes f Heath in Bethesda, Mayand, and they went f an inteview. ige and 16 the patients wee aepted.
Fist the dts emved white bd es aed ymphytes fm the patients; the es ae the wais f the immne system. The ymphytes wee paied with the vis that dts had genetiay engineeed in the ab t seek t ane tms and attah t them. The hpe was that the spe-immne es wd desty the tms.
ne the immne es had been genetiay engineeed, patients ndewent hemtheapy t ki mst f thei igina immne es. Then the new jied-p es wee infsed bak int the bdy and the patients wee given a teatment aed Inteekin 2, whih stengthens the new immne system.
When veteans in the fied f ane, wh have had thei hpes dashed many times, tak f a stdy being the beginning f a new hapte in ane teatment, it daws attentin. And sevea pminent ane eseahes td NN that this stdy is an imptant mment in teatment f the disease.
"This nts," says D. en ihtenfed f the Ameian ane Siety. "It's eay, bt it's the beginning f a new appah."
The next step f senbeg is anthe inia tia with ptentiay stnge gene theapy, and he expets t hea in the next few weeks whethe the FDA has appved the tia. He aknwedges that mh wk ies ahead, bt he beieves that in the ng n this appah wi wk n abt haf f a mmn anes.
The exta mnths Mak ige neve expeted t have have bght sme amazing memies. ast Septembe ne f his deams ame te: He waked his daghte Katie dwn the aise.
"It was a fantasti day," he says f the wedding. "It was a eebatin, a eebatin f ife. It was the beginning f my daghte's ife, he new ife, and the beginning f my new ife تم الترخيص للعلاج وهو عباره عن فيروس يلتصق بالخلايا السرطانية ولايلتصق بالخلايا السليمة ويدمر الخلايا السرطانية ويقوم بتنشيط جهاز المناعة ويعتبر بداية كبيره لعلاج السرطان.
باحث باثيولوجي(تخصص طب بشري) الموضوع مفيد جدا لمرضي السرطان المصدر سي ان ان
PSTED: 9:52 p.m. EDT, Agst 31, 2006
va ikExpie = "-1";By histy Feig
NN
Adjst fnt size:
BETHESDA, Mayand (NN) -- Instead f sing sgey, hemtheapy, adiatin, eseahes fm the Natina Instittes f Heath ae finding s-fa imited bt inspiing sess in a new appah f fighting ane, sing the immne system t attak the tms the way it wd a d f.
The hman immne system desn't say fight ane n its wn, s D. Steven senbeg and his NIH eages ae tying t genetiay enginee it, sing a vis they eated in the ab that seeks t ane tms and attahes t them.
senbeg's idea: Mix the es that seek t the ane with the immne es that desty things and see whethe it wd eate a st f smat bmb f the ane. (senbeg: 'Jst a stat')
In the stdy, senbeg tested the appah in 17 patients with advaned meanma, a danges fm f skin ane. A the nventina teatments f the disease aeady had faied in a f the patients.
In 15 f the patients senbeg's engineeed immne-e teatment didn't wk, bt in tw f the patients the ane seems t have mpetey disappeaed. The findings ae pbished in this week's isse f the jna Siene. (Wath hw teatment tk dad dwn the aise -- 3:06)
The finding has eated exitement and hpe amng ane expets. D. Phiip Geenbeg f the nivesity f Washingtn Sh f Mediine aed it "the beginning f a new hapte in teating ane patients."
ne f the patients in whm the teatment seeded is Mak ige fm Watetwn, Wisnsin.
He was fist fnd t have meanma in 1999 in a me n his bak. Afte sgey, it went away. Bt thee yeas ate the ane ame bak. He tied many teatments bt by 2004 nthing was wking, and the ane had spead t his ive.
"I was jst petty mh devastated when I fnd t I did nt espnd," he says. "ight abt that time my daghte gt engaged and I knew thee was ging t be a wedding ming p, s thee was nen. I wanted t be thee."
Thgh nine eseah, his wife fnd senbeg's inia tia at the Natina Instittes f Heath in Bethesda, Mayand, and they went f an inteview. ige and 16 the patients wee aepted.
Fist the dts emved white bd es aed ymphytes fm the patients; the es ae the wais f the immne system. The ymphytes wee paied with the vis that dts had genetiay engineeed in the ab t seek t ane tms and attah t them. The hpe was that the spe-immne es wd desty the tms.
ne the immne es had been genetiay engineeed, patients ndewent hemtheapy t ki mst f thei igina immne es. Then the new jied-p es wee infsed bak int the bdy and the patients wee given a teatment aed Inteekin 2, whih stengthens the new immne system.
When veteans in the fied f ane, wh have had thei hpes dashed many times, tak f a stdy being the beginning f a new hapte in ane teatment, it daws attentin. And sevea pminent ane eseahes td NN that this stdy is an imptant mment in teatment f the disease.
"This nts," says D. en ihtenfed f the Ameian ane Siety. "It's eay, bt it's the beginning f a new appah."
The next step f senbeg is anthe inia tia with ptentiay stnge gene theapy, and he expets t hea in the next few weeks whethe the FDA has appved the tia. He aknwedges that mh wk ies ahead, bt he beieves that in the ng n this appah wi wk n abt haf f a mmn anes.
The exta mnths Mak ige neve expeted t have have bght sme amazing memies. ast Septembe ne f his deams ame te: He waked his daghte Katie dwn the aise.
"It was a fantasti day," he says f the wedding. "It was a eebatin, a eebatin f ife. It was the beginning f my daghte's ife, he new ife, and the beginning f my new ife تم الترخيص للعلاج وهو عباره عن فيروس يلتصق بالخلايا السرطانية ولايلتصق بالخلايا السليمة ويدمر الخلايا السرطانية ويقوم بتنشيط جهاز المناعة ويعتبر بداية كبيره لعلاج السرطان.
باحث باثيولوجي(تخصص طب بشري) الموضوع مفيد جدا لمرضي السرطان المصدر سي ان ان
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