medicinal chemistry

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أكبر موسوعة علميه للميديسينال (mediina hemisty )
سلام يا أعضاء منتدى الصيدلة
كيفكم وشو أخباركم
ان شاء الله في هالموضوع راح أكتبلكم كل يوم عن الmediina hemisty لدواء معين وشكل الhemia stte فيه

أولا)أبدأ عن ال imetidine (سيميتيدين) وهو عبارة عن H2 eept antagnist


يحتوي هذا المركب على حلقة imidaze الضرورية لعمل المركب ويجب ان يكون هناك 4 ذرات تفصل الimidaze ing عن الN atm
MA:الدواء يبطل عمل الهيستامين في خلايا المعدة لذلك فهو يقلل من افراز حامض الH من هذة الخلايا
استعمالاته:1)ستعمل هذا الدواء لعلاج dyspepsia (عسر الهضم)
2) يستعمل لعلاج الGED (الحرقة)
في الماضي كان يستعمل لعلاج القرحة لكن بسبب الاثار الجانبية لجئ الاطباء الى استعمال الPPI مثل الmepaze
مثال لأسم تجاري له :(Tagamet)
ثانيا) famtidine

وهو ايضا عبارة عن H2 eept antagnist لكن في هذا المركب تم استبدال imidaze ing ب ganidinthiaze ing لذلك يعتبر أقوى 30 ضعف من الemitidine
وله نفس استعمالات السيميتيدين ولكن أثاره الجانبية اقل.
الاسم التجاري :Pepid
 
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ثالثا) mepaze


يحتوي هذا المركب على benzimidaze ing وهي الاهم لعمل المركب.

it is ptn pmp inhibit (PPI) bease it is ievesibe inhibit H+K+ ATPase byxidatin f sfhydy gp in the paieta e membane enzyme.

استعمالاته: 1) عسر الهضمdyspepsia) )
2) pepti e disease (القرحة المعدية)
يستعمل مع ال aithmyin and metnidaze للقضاء على البكتيريا المسببة للقرحه بالمعدة التي تسمى H.pyi
3) Zinge-Eisn syndme وهو نوع من أنواع السرطان بالمعدة عافاكم الله
4) GET

الاسم التجاري:se

اتمنى للجميع الاستفادة وسامحوني كلمة بالعربي وكلمة بالانجليزي !!!!!!!
 
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رابعا) Dzamide

it is sfnamide deivative
mst have sfnamide gp(S2-NH2) that is itia f atin

it is a type f dietis that at n pxima tbes in kidney.it is mst ptant abni anhydase inhibit>and nside an anti gama agent.
أستعمالاته
sed f teatment f gama bz it deease the biabnate in n. in a fid.
 
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خامسا) hydhthiazide




it is Benzthiadiazines deivatives
sfnamide gp is essentia f ativity
as atm B F3 the ipphii gp n psitin 6 is essentia f ativity
sbstittin at psitin 3 with ipphii gp wi inaese the pteny
and as at psitin 2 inease the pteny exept if highe aky gp that deease the pteny
MA: 1) inhibit Na+ eabsptin at dista tbes
2) enhane K+ exetin
ses: sed f teatment f hypetentin and dema

أي ترجمة للعربي انا جاهزة ان شاء الله
 
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سادسا ) fsemide



it is type f dietis
stte ativity eatinship : sfamay benzi aid deivative
fee sfnamide gp (S2NH2) is essentia f ativity
as the abxyi aid is essentia f ativity
mehanism f atin: it inhibit Na+K+2 tanspt system in the thik asending imp f henes p
ses: teatment f dema and sed in hypetentin
 
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سابعا) amiide



Ptassim spaing dietis
SA: Pyazine deivative
this pd have Pyazine ing that is essentia f ativity
the ptima ativity when atm at psitin 6 and NH2 at psitin 3,5
ses:sed t teatment f mid dema assiated with ngistive heat faie ive ihsis and nephti syndm.
MA: at n the temina 12 13 f the dista nvted tbe.
ntes: this pd an ase hypekaemia s it sed in mpenatin with thiazide bz ne f the thiazide side effet is hypkaemia
 
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أدوية الضغط
veapami



Veapami is a aim hanne bke and inhibits the
enty f aim thgh aim hannes int
adivasa es.
stte ativity eatinship: it is a pheny akyamine deivative. it have B ay ethy amine gp that is a itia f ativity.


MA: The pinipa effets f veapami ae n the adivasa
system. It deeases ativentia ndtin and has a
negative intpi effet. It has a vasdiating atin n
the vasa system.

ses: sed in sme ases f hypetentin,angina pets
as sed as antiaythmi agent.
 
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ditiazem



aim hanne bke
its phamagia ativity mainy simia t veapami
SA: Benzthiazepine deivative
ses:in sme ases f hypetentin ,angina pets ,aythmia
 
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nifedipine


fist geneatin aim hanne bke
it is dihydpyidine deivative
______________________________
amdipine

send geneatin aim hanne bke
as dihydpyidine deivative
_____________________________________
aptpi



it is AE-I (Angitensin nveting enzyme inhibit)I
ass: sfhydy deivative (sfhydy inhibit )
___________________________________________

enaapi

AE-I
ass: diabxy deivative
_______________________________
fsinpi


AE-I
ass:ganphsphs deivative

مع تحياتي :عاشقة الميديسينال in10;in10;
 
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يتبع .....
أدوية السكري

1) tbtamide



fist geneatin sfny ea deivative
it is hypgyemi agent
sed f teatment f diabetis meits


2) Gibenamide



send geneatin sfny ea deivative
as it is hypgyemi agent
have nge datin f atin than 1st geneatin


3) Gimepiide



thid geneatin sfny ea deivative
it is hypgyemi agent sed f
teatment f diabetis meits
 
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4) metfmine



it is biqanide deivative
type f hypgyemi agent that sed
t teatment f diabetis meits
the main side effet f it is ati aedsis

5) pigitazne



a hypgyemi agent
it is thiazidinedin deivative
it sensitize taget tisse t the effet f insine witht stimating insine seetin fm beta e.

6) epaginide



a hypgyemi agent
ethxy benzi aid deivative
it stimate eease f insine by seetive inhibitin f K+ATPase hanne in the b e
 
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بعد فترة راحة طويله أعود اليكم مرة اخـــــرى وكلي حماس ... بمجموعة جديدة من الادويه

Antiagant and antipateets dg

1) Hepain



nfatinated hepaine
it is a gsamingyan deivative
nsist f bth gsamine nit and ni aid nit
mehanism f atin : it aeaate the atin f Antithmbin 3 s inhibit thmbin and fat Xa (by fming a tenay mpex)
it mst ntain nt ess than 18 sahaide nit
ses: as antiagant f vens thmbsis (PE & DVT )
main side effet : thmbytpenia ( HIT )
ay inative

2) Enxapaine
MWH



it pde me pidetabe espnse and have bette biaveabiity than hepaine
MA : bind and aeaating the ativity f AT 3 t bind with thmbin and make it inative
sed in teatment f vens thmbsis
ay inative
 
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3) wafaine



main deivative
(hydxy maine deivative)
sed f teatment and peventin f vens thmbsis
MA : it inhibit the synthesis f vitamine K dependent agatin fate 2 ,7 ,9 , 10 and ptien S and
it exet its effet by inhibiting vit.K epxide edtase and vit. K edtase
ay effetive

يتبع قريبا جدا ............
 
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antipateate Dg

1) Dipyidame



اعذروني لم اجد اصغر منها
pipeidiny pyimid pyimidine deivative
it is nn nitate nay vasdiat.
MA:1- inhibit adensine deaminase s ead t amate f adensine that is ptent vasdiat
2- inhibit phsphdiestease s deay the hydysis f AMP ead t deease fee a+ that is paggegate

2) aspiin



aetysaiyi aid deivative
MA : iivesibe aetyate the pateate yxygenase enzyme and inhibit thmbxane A2 pdtin
ses: antipateat as pphyati , anagesi ,antiinfammaty , antipeti

3) tipidine



thienpyidine deivative
sed f ateia thmbi ( stke and TIA )
MA : inhibit ADP inded peteate -fibingen binding and peteat - peteat inteatin
 
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4) pidgi



thienpyidine deivative
MA : it inhibit the binding f ADP t its peteat eept s inhibit the sbseqent ADP-mediated ativatin f GP 2b\3a mpex
nte : it is pdg need t bitansfmatin

5) tifiban



btysfny tysine deivative
it bk GP 2b\3a s inhibit peteat fm nneting t eah the s peventin the fmatin f t

6) eppsten



it is anage f pstayin ( vasdiat )I
MA : the antipeteat effet mediated by stimatin f adenyyase s inease AMP

antipateat انتهى
تحياتـــــي لكم
وشكر خاص لدكتور المادة
قريبا جدا مجموعة اخرى من الادويه
 
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antipakinsnian agent
1)antihinegi dg
2)dpamine pes
3)dg inease the eease f dpamine
4)dpamine eept agnist
5)MA inhibit
6)MT inhibit


antihinegi agent
1)gentin

amin ethy deivative


2) ethppazine

phenthiazine deivative


dpamine pes
1) evdpa


it wi g t bain and s ndeg deabxyatin s nveted t dpamine
nte : mst sed in mbinatin with abidpa (peiphea dpamine deabxyase inhibit)I t pevent the deabxyatin pess in the peiphea tisse s wi inease the n. f the evdpa in the bain

abidpa stte
 
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تابــــع... antipakinsn agent
dg inease the eease f dpamine
amantadine

it stimate the eease f dpamine fm the stage aea
may sed in mbinatin f evdpa
it as deay the eptake f dpamine by neve teminas and may have sme antihinegi effet


egine dpamine eept agnist
1) bmiptine

it is egine deivative (egpeptide)I
it is diet stimatin f dpamine eept (seetive f D2 eept)I


2) pegide

egine deivative
at as dpamine agnist


3)abegine

egine deivative
stimate D2 eept
 
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تابع ... antipakinsn agent
nn egine dpamine eept agnst
1) pamipexe

ppy aminbenzthiaze deivative
at n D2 eept
it as have antixidant ativity s penefit t ths patient t ptet him fm fee adia fmatin


2) pinie

inde deivative
have highe affinity f D2,D3 eept
at as nn egine dpamine agnist


MA inhibit
seegiine

it is seetive inhibit f MA-B enzyme s inhibit the metabism f dpamine and ineade its nentatin
nt sed ane bt is is sed in mbinatin with evdpa


MT inhibit
1)entaapne

nitatehs deivative
sed t teatment f pakinsn disease by inhibit MT enzyme

انتهى antipakinsn agent
الى اللقاء مع مجموعة اخرى من الادويه ان شاء الله y_1
 
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