: What is the mst ikey diagnsi n examinatin:
-this disease shws geneaized (systemi) symptms. Fig 10.25
1- Feve
2- jints: Jint invvement is the mst mmn inia feate, sma jint pyathpathy .
3- skin:
eent phtsensitive ash , in bttefy distibtin n the heeks f the fae and ass the bidge f the nse
Apeia
d
4- The ngs: intemittent peiti dismft.
5- The kidneys: pteinia
6- The nevs system: migaine ike headahes.
7- The eyes: njntivitis.
8- The gastintestina tat:
Nasea.
Abdmen pain.
Investigatin:
1. Maked anemia “atimmne hemyti anemia”
2. Psitive -eative ptein.
3. High eve ANA (antinea antibdy).
4. High eve f anti-DNA antibdies.
2: What is the etigy f this disease?
nknwn, bt thee is pedispsing fats. The mst ikey pedispsing fat in this nditin is “sex hmne stats”
Fat :
1) Heedity.
2) Genetis
3) mpement
4) Sex hmne stats: pemenpasa wmen , mae with kinefete (XXY)
5) Dg
6) V
7) Vises
3: What ae the immngia fats assiated with this disease?
1. Ativatin f B e ests eventay in an inease f antibdies.
2. Faie t emve immne mpexes fm the iatin eads t depsitin f mpexes in the tisse asing damage.
3. Impaied T e egatin whih ests in me desttin and me ativatin t the es e.g. B e.
4. Abnma ytkine pdtin (I-1 and I-2) whih stimates the T es.
5. TNF-a pmte pymphisms.
4: What is the pathgenesis f the disease?
SE is a faie t maintain sef-teane “atimmne disease” and faie t ea nea mateia fm apptti es and nea mateia being in exess and pssiby in ateed fm. These nea mateia is taken by antigen pesenting e e.g. maphage whih pesented t T e (whih st its teane against sef-antigen), T e wi stimate B-e pding antibdies against nea antigens whih ests in damage.
Beside, ANAs an eat with nei f damaged es ead t hmatin hanges t pde s-aed E bdies hematxyin bdies.